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FAQ and common issues
My basecalling speed is a lot slower than it was the last time I ran Guppy.
This is most likely because the model you are using is different. The default configuration for Guppy is to use High Accuracy models, and these will be quite a lot slower than the "fast" models that Guppy used to have as a default. See the above section Setting up a run: configurations and parameters.
When I run the GPU version of Guppy I get the message
error while loading shared libraries: libcuda.so.1: cannot open shared object file
.This will happen when NVIDIA GPU drivers for Guppy have not been installed, or have been installed incorrectly. (Re)installing GPU driver packages should solve this.
I get slightly different results from Guppy when I run on different platforms or with different GPUs.
Guppy should provide completely deterministic and repeatable results for a given platform, operating system, GPU, and GPU driver, but its output may be slightly different if any of those things change. The overall basecall results should be very similar, and in most cases completely identical.